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癌症成像和声音和光线

In 2003, Dr。 Lihong V。 Wang at Washington University introduced one of the most exciting technologies we’;ve had the chance to see in a long while。 By combining ultrasound and light absorption, Wang and colleagues developed a new method that makes multicontrast images of biological tissues several inches below the skin。 Among others, this allows specialists to see cancer in action with unprecedented detail and provide a faster and more accurate diagnosis。 Recently, Want and colleagues at Washington University published a paper that refines this innovative optical imaging method by using what they call “time-reversal” technology that allows for better-focused light in tissue, such as muscles and organs。

Peering through the skin

 a) Optical-resolution photoacoustic microscopy of sO2 in a mouse ear; b) acoustic-resolution photoacoustic microscopy of normalized total hemoglobin concentration, (hemoglobin), in a human palm; c) linear-array photoacoustic CT of normalized methylene blue concentration, (dye), in a rat sentinel lymph node (SLN); d) circular-array photoacoustic CT of cerebral hemodynamic changes, Δ(hemoglobin), in response to one-sided whisker stimulation in rat; e) photoacoustic endoscopy of a rabbit esophagus and adjacent internal organs, including the trachea and lung。 UST = ultrasonic transducer。 Courtesy of Dr。 Lihong V。 Wang。

a) Optical-resolution 大发官方娱乐photoacoustic microscopy of sO2 in a mouse ear; b) acoustic-resolution photoacoustic microscopy of normalized total hemoglobin concentration, (hemoglobin), in a human palm; c) linear-array photoacoustic CT of normalized methylene blue concentration, (dye), in a rat sentinel lymph node (SLN); d) circular-array photoacoustic CT of cerebral hemodynamic changes, Δ(hemoglobin), in response to one-sided whisker stimulation in rat; e) photoacoustic endoscopy of a rabbit esophagus and adjacent internal organs, including the trachea and lung。 UST = ultrasonic transducer。 Courtesy of Dr。 Lihong V。 Wang。

Called photoacoustic tomography (PAT), the technique achieves imaging depth by combining the spatial resolution of ultrasound with the high contrast resulting from light absorption by colored molecules such as hemoglobin or melanin。 Typically, high-resolution optical imaging technology allows researchers to see about 1 millimeter deep into the body。 PAT, however, can peer through biological matter at depths as big as 7cm!

What makes PAT really exciting is its ability to reveal the use of oxygen by tissues。 When oxygen is burned in excess (hypermetabolism), this is usually a telltale sign that cancer is lurking。 Diabetes also causes hypermetabolism。 By using PAT, doctors can analyze patient tissue and provide an early-warning diagnosis without using a contrast agent –; a big game changer!

本文源自: 环亚娱乐游戏

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